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应用高压液相色谱法检测三种肝病患者尿中粪卟啉同分异构体含量,并同时检测静脉色氰酸耐量试验.血清胆红素浓度和白蛋白浓度。结果表明:肝硬化组尿中粪卟啉Ⅰ型,游离色氨酸以及白蛋白浓度均与慢活肝组和急性肝炎组有显著差异。提示肝脏的转运功能障碍是尿中粪卟啉同分异构体含量变化的基本因素。对伴有高胆红素血症的肝硬化患者的有关指标作相关分析提示:血清胆红素可能干扰卟啉代谢。
High-pressure liquid chromatography (HPLC) was used to detect urine fecal porphyrin isomers in the three kinds of liver disease patients, and at the same time, the intravenous cyanic acid tolerance test, serum bilirubin concentration and albumin concentration were measured. The results showed that the urinary genotypes of coproporphyrin, free tryptophan and albumin in cirrhosis group were significantly different from those in chronic liver disease group and acute hepatitis group. Prompt dysfunction of liver transport is the basic factor of urine fecal porphyrin isomers changes. Correlation analysis of related indicators of cirrhotic patients with hyperbilirubinemia suggests that serum bilirubin may interfere with the metabolism of porphyrin.