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目的旨在探讨细胞周期蛋白Ｄ１（ｃｙｃｌｉｎＤ１）在早期诊断宫颈鳞癌中的意义。方法采用ＡＢＣ免疫组化及地高辛精原位杂交技术检测９６例经福尔马林固定、石蜡包埋的宫颈组织标本中ｃｙｃｌｉｎＤ１的表达情况。结果宫颈鳞状上皮癌（宫颈鳞癌）与宫颈鳞状上皮非典型增生（非典型增生）之间无显著差异（Ｐ＞００５），但显著高于慢性宫颈炎和正常宫颈组织（Ｐ＜００５）。且与病理分级相一致（Ｐ＜００５）。结论宫颈鳞癌及其癌前病变中ｃｙｃｌｉｎＤ１均有较高水平的表达，可能成为宫颈鳞癌临床筛选诊断的指标之一。
Objective To investigate the significance of cyclin D1 in early diagnosis of cervical squamous cell carcinoma. Methods ABC immunohistochemistry and in situ hybridization were used to detect the expression of cyclinD1 in 96 specimens of formalin-fixed and paraffin-embedded cervical tissue. Results There was no significant difference between cervical squamous cell carcinoma (cervical squamous cell carcinoma) and atypical hyperplasia (atypical hyperplasia) of cervical squamous epithelium (P> 0.05), but significantly higher than that of chronic cervicitis and normal cervical tissue (P <005). And consistent with the pathological grade (P <0 05). Conclusion The expression of cyclinD1 in cervical squamous cell carcinoma and its precancerous lesions may be one of the clinical diagnostic criteria for cervical squamous cell carcinoma.