BACKGROUND AND OBJECTIVE: To compare the use of cyclocryotherapy and diode laser cyclophotocoagulation for the treatment of uncontrolled intraocular pressure. P ATIENTS AND METHODS: Seventy consecutive patients (70 eyes)-treated for high, u nresponsive intraocular pressure during a 4-year period with cyclocryotherapy ( n=38) or diode laser cyclophotocoagulation (n=32) with a follow-up period of at least 3 months (mean follow-up=15.7 months) were compared for intraocular pres sure, visual acuity, and complication rate. RESULTS: Mean intraocular pressure w as reduced from 40.9 ±11.9 to 20.5 ±10.3 mm Hg in the cyclocryotherapy group, and from 35.9 ±9.3 to 21.3 ±10.7 mm Hg in the cyclophotocoagulation group. Int raocular pressure was controlled in 60.5%and 62.5%of eyes, respectively. Deter ioration in visual acuity occurred in 31.5%of the cyclocryotherapy group and 37 .5%of the cyclophotocoagulation group. Severe visual loss to no light perceptio n was noted in 6 eyes and 2 eyes, respectively, and phthisis bulbi in 2 eyes in the cyclocryotherapy group (5.2%) and 1 eye in the cyclophotocoagulation group (3.1%). CONCLUSIONS: Cyclocryotherapy and diode laser cyclophotocoagulation are equally effective in decreasing intraocular pressure in patients with persisten t uncontrolled glaucoma, with a lower rate of complications associated with diod e laser cyclophotocoagulation. BACKGROUND AND OBJECTIVE: To compare the use of cyclocryotherapy and diode laser cyclophotocoagulation for the treatment of uncontrolled intraocular pressure. P ATIENTS AND METHODS: Seventy consecutive patients (70 eyes) -treated for high, u nresponsive intraocular pressure during a 4-year period with cyclocryotherapy (n = 38) or diode laser cyclophotocoagulation (n = 32) with a follow-up period of at least 3 months (mean follow-up = 15.7 months) were compared for intraocular pres sure, visual acuity, and complication rate. : Mean intraocular pressure w as reduced from 40.9 ± 11.9 to 20.5 ± 10.3 mm Hg in the cyclocryotherapy group, and from 35.9 ± 9.3 to 21.3 ± 10.7 mm Hg in the cyclophotocoagulation group. Int raocular pressure was controlled in 60.5% and 62.5% of eyes, respectively. Deterioration in visual acuity occurred in 31.5% of the cyclocryotherapy group and 37 .5% of the cyclophotocoagulation group. Severe visual loss to no light perceptio n was noted in 6 eyes and 2 eyes, respe ctively, and phthisis bulbi in 2 eyes in the cyclocryotherapy group (5.2%) and 1 eye in the cyclophotocoagulation group (3.1%). CONCLUSIONS: Cyclocryotherapy and diode laser cyclophotocoagulation are equally effective in reducing intraocular pressure in patients with persisten t uncontrolled glaucoma, with a lower rate of complications associated with diod e laser cyclophotocoagulation.