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目的:观察急性冠状动脉综合征(ACS)患者妊娠相关血浆蛋白A(PAPP-A)水平的变化。方法:冠状动脉造影(CAG)证实的冠心病患者80例,分为ACS组(53例)、稳定型心绞痛(SA)组(27例),以23例CAG正常者为正常对照组;测定各组患者入院时外周血清PAPP-A水平,分析不同组别间及ACS组、SA组中冠状动脉病变不同程度者PAPP-A水平的变化,并分析PAPP-A水平与TnT、CK-MB的相关性。结果:①ACS组的PAPP-A水平显著高于正常对照组和SA组(P<0.01),正常对照组与SA组之间及ACS组中不稳定型心绞痛和急性心肌梗死亚组PAPP-A水平比较差异均无统计学意义(P>0.05);②PAPP-A水平与CK-MB、TnT水平无显著相关;③ACS组、SA组中冠状动脉病变不同程度亚组PAPP-A水平比较差异均无统计学意义(P>0.05)。结论:检测PAPP-A水平对ACS早期诊断可能有一定的意义,但冠状动脉病变程度与PAPP-A水平无显著相关。
Objective: To observe the change of pregnancy related plasma protein A (PAPP-A) in patients with acute coronary syndrome (ACS). Methods: Eighty coronary artery disease patients confirmed by coronary angiography (CAG) were divided into ACS group (n = 53) and stable angina pectoris group (n = 27). Twenty-three normal subjects with CAG were selected as normal control group. The level of PAPP-A in peripheral blood serum of patients in group A and group B were compared. The change of PAPP-A level in different groups, ACS group and SA group were analyzed. The correlation between PAPP-A level and TnT and CK-MB Sex. Results: ① The PAPP-A level in ACS group was significantly higher than that in normal control group and SA group (P <0.01). PAPP-A level in unstable angina pectoris group and acute myocardial infarction group in normal control group and SA group as well as in ACS group (P> 0.05) .②PAPP-A level had no significant correlation with CK-MB and TnT levels. ③ There was no statistical difference in PAPP-A levels between ACS group and SA group in different degrees of coronary artery disease Significance (P> 0.05). Conclusion: The detection of PAPP-A level may have some significance for the early diagnosis of ACS, but the degree of coronary artery disease has no significant correlation with PAPP-A level.