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目的:研究盐酸川芎嗪注射液(ILH)抗脑缺血损伤作用。方法:大鼠脑梗塞模型用大脑中动脉结扎法制备;血管灌流量测定在离体免耳上进行。结果:ILH40mg.kg~(-1)iv显著改善大鼠异常神经症状,降低梗塞脑组织重量和抑制乳酸脱氢酶(LDH)活性的下降,200mg·L~(-1)ILH可显著增加免耳灌流量。结论:ILH有抗缺血性脑损伤作用,其作用可能与扩张脑血管有关。
Objective: To study the effect of ligustrazine hydrochloride injection (ILH) against cerebral ischemia injury. METHODS: Rat cerebral infarction models were prepared by ligation of the middle cerebral artery; vascular perfusion measurements were performed on isolated ears. RESULTS: ILH40mg.kg~(-1)iv significantly improved abnormal neurological symptoms, decreased brain tissue weight and inhibited the decrease of lactate dehydrogenase (LDH) activity. 200mg·L~(-1)ILH significantly increased Ear irrigation flow. Conclusion: ILH has anti-ischemic brain damage, and its effect may be related to the expansion of cerebral blood vessels.