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本文测定了32例肥胖儿和年龄及性别配对的正常健康儿血脂和载脂蛋白水平,使用相对体重,Kaup指数,上臂围,体脂含量和皮褶厚度总和作为肥胖的评价指标,肩胛下与三头肌皮褶厚度比值(STR)评价脂肪分布情况。采用Sclaro法测定TG,TC和HDL-C。免疫圆周扩散法测定APO-AI,B100,CⅡ和CⅢ。结果表明:肥胖儿血HDL-C,HDL-C/TC,APO-AI和APO-CⅡ/CⅢ比显著降低,TG,VLDL-C,APO-B100,APO-CⅢ,动脉硬化指数和APO-BlOO/AⅠ显著升高,并与肥胖程度显著相关。多元分析表明:TSFT与HDL-C显著相关,STR主要影响VLDL-C和APO-CⅡ/CⅢ。结果提示:肥胖可影响血脂和载脂蛋白水平;载脂蛋白和脂肪异常分布是血脂变化的主要原因之一;肥胖儿的确有发生动脉粥样硬化的危险。
In this paper, we measured the levels of lipids and apolipoproteins in 32 healthy children with normal healthy age-and-sex pairs. Using the relative body weight, Kaup index, upper arm circumference, body fat content and skinfold thickness as the evaluation indexes of obesity, Triceps skinfold thickness ratio (STR) evaluation of fat distribution. The Sclaro method was used to determine TG, TC and HDL-C. Immuno circular diffusion method for the determination of APO-AI, B100, CⅡ and CⅢ. The results showed that the HDL-C, HDL-C / TC, APO-AI and APO-CⅡ / CⅢ ratios in obese children were significantly lower than those in control group / A I increased significantly, and significantly correlated with the degree of obesity. Multivariate analysis showed that TSFT was significantly associated with HDL-C and STR mainly affected VLDL-C and APO-CII / CIII. The results suggest that: obesity can affect blood lipids and apolipoprotein levels; anomalous distribution of apolipoprotein and fat is one of the main causes of blood lipids; obese children indeed have the risk of atherosclerosis.