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目的探讨血管内皮生长因子(vascular endothelial growth factor,VEGF)、基质金属蛋白酶-7(matrixmetalloproteinases-7,MMP-7)表达与大肠癌进展及预后的关系。方法采用免疫组化技术检测81例大肠癌(CC)中VEGF及MMP-7的表达。结果VEGF的表达与大肠癌的浸润深度、淋巴结转移、远处转移、Dukes分期呈正相关,MMP-7表达与大肠癌的淋巴结转移、远处转移、Dukes分期呈正相关,黏液癌中表达明显高于高分化腺癌,年龄低于60岁的大肠癌患者MMP-7表达显著强于60岁及60岁以上者。VEGF与MMP-7表达呈正相关。结论MMP-7,VEGF促进了大肠癌组织的生长和转移,具有协同作用,可作为大肠癌的预后评估因子,联合检测以上指标对评估大肠癌的预后可能更准确。降低MMP-7,VEGF的表达和活性可能成为抗肿瘤转移治疗的一个新途径。
Objective To investigate the relationship between the expression of vascular endothelial growth factor (VEGF), matrixmetalloproteinases-7 (MMP-7) and the progression and prognosis of colorectal cancer. Methods Immunohistochemistry was used to detect the expression of VEGF and MMP-7 in 81 cases of colorectal cancer (CC). Results The expression of VEGF was positively correlated with the depth of invasion, lymph node metastasis, distant metastasis and Dukes stage in colorectal cancer. The expression of MMP-7 was positively correlated with lymph node metastasis, distant metastasis and Dukes stage in colorectal cancer, In well-differentiated adenocarcinoma, the expression of MMP-7 in patients with colorectal cancer younger than 60 years old was significantly higher than that in patients 60 years old and older. VEGF and MMP-7 expression was positively correlated. Conclusions MMP-7 and VEGF can promote the growth and metastasis of colorectal cancer, and have a synergistic effect. MMP-7 and VEGF can be used as a prognostic factor for colorectal cancer. Combined detection of the above indexes may be more accurate in assessing the prognosis of colorectal cancer. Decreasing the expression and activity of MMP-7 and VEGF may become a new way of anti-tumor metastasis treatment.