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许多前瞻性研究提示血清Vit A浓度与癌症的发生呈负相关,肺癌和胃癌尤为明显。后来发现这是因癌症早期Vit A浓度降低所致。Wald等报导血清Vit A浓度与随后发生的乳腺癌无关,但与对照组比较,β—胡萝卜素浓度降低,Vit E(α—生育酚)浓度升高。Willet等进行的包括肺癌、乳腺癌在内的Vit A、β—胡萝卜素、Vit E浓度与癌症发生的前瞻性研究,没有发现直接联系,但Menkes等报导低浓度Vit E与肺癌发生有关。用新的方法进行乳腺癌前瞻性研究,重新探讨这个问题,采自根西岛地区5000名妇女的血清标本用高压液相法(HPLC),包括类似
Many prospective studies suggest that serum Vit A concentration is inversely related to the occurrence of cancer, especially in lung and gastric cancer. It was later discovered that this was due to a decrease in the concentration of Vit A in the early stage of cancer. Wald et al. reported that the concentration of serum Vit A was not related to the subsequent breast cancer, but compared with the control group, the concentration of β-carotene was decreased and the concentration of Vit E (α-tocopherol) was increased. Willet et al. conducted a prospective study of the concentrations of Vit A, β-carotene, and Vit E, including cancers of the lung, and breast cancer, and found no direct connection, but Menkes et al. reported that Vit E was associated with lung cancer. Prospective studies of breast cancer using new methods to revisit this issue. Serum samples taken from 5,000 women in the Guernsey region were analyzed by high pressure liquid chromatography (HPLC).