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目的观察微生态制剂金双歧(双歧杆菌、乳杆菌和嗜热链球菌三联活茵片)对腹痛儿童幽门螺杆菌根除治疗的影响。方法将54例幽门螺杆菌(H.pylori)阳性的腹痛儿童随机分成A组(奥美拉唑、克拉霉素、阿莫西林三联疗法)和B组(金双歧联用三联疗法),疗程均为2周,治疗结束4周后复查13C-尿素呼气试验,统计患儿治疗期间的不良反应。结果 A、B两组根除根除率分别为74.3%和88.8%,差异无统计学意义(P>0.05);B组胃肠道不良反应明显少于A组(P<0.01)。结论微生态制剂不能显著增加腹痛儿童幽门螺杆菌根除率,但降低三联根除疗法的胃肠道不良反应。
Objective To observe the effects of the probiotics Jin bifidobacterium (Bifidobacterium, Lactobacillus and Streptococcus thermophilus) on Helicobacter pylori eradication in children with abdominal pain. Methods 54 cases of H.pylori positive abdominal pain children were randomly divided into group A (omeprazole, clarithromycin, amoxicillin triple therapy) and group B (jin bifu combined with triple therapy), treatment were 2 weeks, after the end of treatment for 13 weeks to review 13C-urea breath test, statistical treatment of children with adverse reactions. Results The eradication rates of group A and B were 74.3% and 88.8% respectively, with no significant difference (P> 0.05). The gastrointestinal adverse reactions in group B were significantly less than those in group A (P <0.01). Conclusions The probiotics can not significantly increase the Helicobacter pylori eradication rate in children with abdominal pain, but reduce the gastrointestinal adverse reactions in triple eradication therapy.