报告５１例ＣＴ导引下肌肉骨胳活检，其中３７例是骨胳系统活检，１４例是肌肉系统活检。活检正确率为９０．２％，假阴性９．８％。为了提高活检正确率需：（１）选择好最佳穿刺层面，穿刺点正确，多点穿刺；（２）骨钻针、切割针和／或抽吸法联合应用；（３）穿刺标本检查包括肿瘤细胞、细菌和具菌；（４）放射科和病理科之间密切的配合。本组未出现严重并发症。对ＣＴ导引下穿刺活检方法、适应证和其优点进行了讨论。ＣＴ寻引下肌肉骨胳活检是一种安全，有效的诊断和鉴别诊断方法。 Fifty-one CT-guided musculoskeletal biopsies were reported in 51 patients, of whom 37 were skeletal biopsies and 14 were muscle biopsies. Biopsy correct rate was 90.2%, false negative 9.8%. In order to improve the accuracy of biopsy need to: (1) choose the best puncture level, the puncture point is correct, more puncture; (2) bone drilling needle, cutting needle and / or suction method in combination; (3) Tumor cells, bacteria and bacteria; (4) the close cooperation between radiology and pathology. This group did not appear serious complications. CT-guided biopsy methods, indications and their advantages are discussed. CT-guided musculoskeletal biopsy is a safe and effective diagnostic and differential diagnosis.