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目的 :了解血清一氧化氮 (NitricOxide ,NO)、血浆降钙素基因相关肽 (CGRP)和内皮素 (ET)与急性高原病的关系和NO对急性高原病的治疗作用。方法 :将 4 7例急性高原病患者随机分为常规药物治疗组 (2 3例 )和NO治疗组 (2 4例 )。并对两组患者治疗前后的血清NO和血浆CGRP、ET的变化情况进行了对照比较 (NO以其代谢终产物NO3-和NO2-表示 )。结果 :两组治疗后的血清NO和CGRP均显著高于该组治疗前 ,ET则显著低于治疗前 ,NO治疗组P <0 .0 1,常规药物治疗组P <0 .0 5。两组治疗后的NO和ET相差亦具有显著性(P <0 .0 5 )。治疗前血清NO含量与血浆CGRP、ET呈显著的相关性 (r =0 .38,P <0 .0 1和r =- 0 .6 3,P <0 .0 0 1)。结论 :急性高原病患者血清NO、血浆CGRP和ET水平的高低与急性高原病的发病有着密切的关系 ,三者有着协调和对抗作用 ,吸入NO治疗急性高原病显著优于常规药物治疗。
Objective: To investigate the relationship between serum nitric oxide (NO), plasma calcitonin gene related peptide (CGRP), endothelin (ET) and acute altitude sickness and the therapeutic effect of NO on acute altitude sickness. Methods: Forty-seven patients with acute altitude sickness were randomly divided into routine drug treatment group (23 cases) and NO treatment group (24 cases). The changes of serum NO, plasma CGRP and ET before and after treatment were compared between two groups of patients (NO is represented by its metabolic end products NO3- and NO2-). Results: Serum NO and CGRP were significantly higher in both groups before treatment than those before treatment, and ET was significantly lower than before treatment, P <0.01 in NO-treated group and P <0.05 in the conventional drug-treated group. The difference between the two groups after treatment of NO and ET was also significant (P <0.05). Pretreatment serum NO levels and plasma CGRP, ET showed a significant correlation (r = 0.38, P <0.01 and r = - 0.63, P <0.001). Conclusion: Serum NO, plasma CGRP and ET levels in patients with acute mountain sickness are closely related to the pathogenesis of acute mountain sickness. The three have coordination and antagonistic effects. NO treatment of acute mountain sickness is significantly superior to conventional medical treatment.