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目的研究紫杉醇联合卡培他滨两种新药治疗晚期胃癌的近期疗效及其毒副作用。方法对病理学证实的21例晚期胃癌患者采用紫杉醇联合卡培他滨治疗。结果全组21例中完全缓解2例,部分缓解11例,稳定5例,进展3例,总有效率61·8%。临床常见毒副反应是骨髓抑制、胃肠道反应及粘膜炎,所有患者均未因毒副作用而中断或退出治疗。结论紫杉醇联合卡培他滨治疗晚期胃癌近期疗效是肯定的,毒副反应轻,病人耐受性好,值得进一步临床研究。
Objective To study the short-term curative effect and side effects of paclitaxel combined with capecitabine on two kinds of new advanced gastric cancer. Methods 21 cases of advanced gastric cancer confirmed by pathology were treated with paclitaxel and capecitabine. Results In the 21 cases of complete remission in 2 cases, partial remission in 11 cases, stable in 5 cases, 3 cases of progress, the total effective rate was 61.8%. Common clinical side effects are myelosuppression, gastrointestinal reactions and mucositis, all patients were not interrupted or withdrawn from treatment due to toxic side effects. Conclusion Paclitaxel combined with capecitabine in the treatment of advanced gastric cancer has a positive curative effect in the near future. It has mild side effects and good patient tolerance. It is worth further clinical study.