论文部分内容阅读
目的了解肝功能衰竭患者的肝组织病理特点,并将病理诊断与临床诊断的结果相比较。方法选择排除肝癌的乙型肝炎病毒感染者39例,将其施行肝移植术后留下的离体肝组织行多部位切取组织标本,进行苏木精-伊红染色及网纤染色,分析其病理特点,并将病理诊断与临床诊断进行比较。结果1．39例离体肝组织标本,整个肝脏病变的范围和程度呈现相对均匀分布的特点,但是在同一取材的微观肝组织中,其病变特点可呈现不均一性。2．临床诊断为“乙肝肝硬化(活动期)”的4例肝组织病理特点均符合“活动性肝硬化”,而35例临床诊断为“慢性乙型重型肝炎”的肝组织病理符合“活动性肝硬化”者有18例、符合“慢性重型肝炎”病理诊断者仅有17例。结论临床诊断为慢性重型肝炎患者在病理学上分为坏死后肝硬化和肝脏大块坏死或亚大块坏死两种类型。
Objective To understand the pathological features of liver tissue in patients with liver failure and compare the results of pathological diagnosis with clinical diagnosis. Methods Thirty-nine patients with hepatitis B virus excluding hepatocellular carcinoma (HCC) were selected. Tissue samples were taken from the ex vivo liver tissue left after liver transplantation for hematoxylin-eosin staining and fibroin staining Pathological features, and pathological diagnosis and clinical diagnosis were compared. Results 1.39 cases of ex vivo liver tissue specimens, the extent and extent of the entire liver lesions showed a relatively uniform distribution of characteristics, but in the same access micro-liver tissue, the lesion characteristics may show heterogeneity. 2. The pathological features of 4 cases of liver cirrhosis (active stage) diagnosed clinically were in line with “active cirrhosis”, while 35 cases of clinical diagnosis of “chronic severe hepatitis B” had liver histopathology consistent with “active liver Sclerosis ”in 18 cases, in line with“ chronic severe hepatitis ”pathological diagnosis of only 17 cases. Conclusion The clinical diagnosis of patients with chronic severe hepatitis is pathologically divided into necrosis of liver cirrhosis and liver necrosis or macular necrosis two types.