【摘 要】
：
Nanosized hydroxyapatite(nsHAp) was synthesized to examine its possibility as a controlled release carrier of protein. To achieve effective protein release from
【机 构】
：
College of Life Science,State Key Laboratory of Inorganic Synthesis and Preparative Chemistry
论文部分内容阅读
Nanosized hydroxyapatite(nsHAp) was synthesized to examine its possibility as a controlled release carrier of protein. To achieve effective protein release from nanosized hydroxyapatite, the study of the adsorptive properties of protein on nsHAp and different influence parameters such as pH, calcium, and phosphate concentrations during the adsorption process is necessary. Ovalbumin(OVA) was selected as the model of growth factors. The results show that the amount of OVA adsorbed onto nsHAp in acetic buffer(pH=3.6) is more than that in acetic buffer(pH=5.6) because of the electric interaction. The amount of OVA adsorption in phosphate buffer solution(PBS) is smaller than that in acetic buffer because of surface complexation and surface hydroxylation. The presence of Ca2+ dramatically increases the adsorbed amount of OVA in acetic buffer on maintaining the same pH. Meanwhile, the release kinetics of OVA adsorbed onto nsHAp(nsHAp-OVA) was also examined. The amount of released OVA in PBS(pH=5.6) was significantly smaller than that released in solution of pH=7.0. All the results suggest that nanosized hydroxyapatite particles could be successfully used as controlled released carrier of protein.
其他文献
Numerous studies have shown that array of transcription factors has a role in regulating plant responses to environmental stresses. Only a small portion of them
The Huangshan granitic intrusion in Anhui province, SE China, is tectonically located at the southeastern boundary of the Yangtze Block. Based on the contact re
甲状腺激素正常的合成及代谢过程，有赖于体内多种微量元素的正常。其中，铁与甲状腺激素的代谢有密切的关系。与碘缺乏一致，铁缺乏也是发展中国家重要的公共健康问题。铁缺乏可以
在机体正常的免疫系统中，Th1和Th2型细胞因子通常维持动态平衡的状态，保持机体正常的免疫功能。研究表明，狼疮性肾炎（ LN）患者体内普遍存在的 Th1和 Th2细胞因子网络失衡是LN的主
In order to evaluate the seismic reliability of water distribution system and make rehabilitation decisions correspondingly, it is necessary to assess pipelines
Modified pectin cross-linked with adipic acid, was synthesized and used for heavy metal removal from wastewater. SEM and FrIR were used to investigate its struc
PVC was subjected to a chemical modification aiming at replacing the chlorine atoms by pyridine groups via a homolytic route. Pyridine groups were peculiarly af
To identify the desired hyperthermophilic variants within a mutant esterase library for the resolution of (R,S)-2-octanol acetate, a simple, reliable, and versa
Hydraulic characteristics of a river are the key factors for river water quality improvement and river restoration. A simulated river was exploited to study the