争光霉素是由链霉菌产生的抗肿瘤抗生素。该产生菌是从浙江平阳的土壤分离得到的。经形态与培养特征等研究表明,该菌株为一新变种.定名为平阳链霉菌(Streptom-yces pingyangensis n.SP)。其产生的抗肿瘤物质为多组分的复合物,各种组分具有共同的主核(糖肽),彼此间的差别在于侧链(末端胺)不同。对争光霉素各组分的理化性质研究表明,其A_2、A_5、B_2等组分与日本报导的博莱霉素相应的组分A_2 、A_5、B_2等相同。我们对争光霉素单一组分A_2、A_5、A_6、B_2 等的抗菌谱及其对小鼠移植性食管癌的组织分布及抑瘤作用进行了比较研究,本文报告研究结果。 材料方法与结果 实验使用的争光霉素各组分是去铜的冷冻干燥粉末,易溶于水,均为单一组分物质。争光霉素A_2、A_4、A_5、A_6、B_2制品是我所化学室与天津河北药厂协作从该厂产品中分 Bleomycin is an antitumor antibiotic produced by Streptomyces. The producing bacteria were isolated from the soil in Pingyang, Zhejiang. The morphological and cultural characteristics of the study showed that the strain is a new variant, named as Streptomyces (Streptomyces pingyangensis n.SP). The anti-tumor substances they produce are multi-component complexes, each component having a common main nucleus (glycopeptide) with the difference from each other that the side chains (terminal amines) differ. The physico-chemical properties of each component of bleomycin showed that the components A_2, A_5 and B_2 were the same as the corresponding components A_2, A_5 and B_2 of bleomycin reported in Japan. Antibiotic spectrum of single components A_2, A_5, A_6 and B_2 of bleomycin, and their tissue distribution and anti-tumor effect on transplanted esophageal cancer in mice were comparatively studied. The results of this study are reported in this paper. Materials Methods and Results The components of the bleomycin used in the experiments were freeze-dried copper-free powders that were readily soluble in water and were all single component substances. Bifenomycin A_2, A_4, A_5, A_6, B_2 products are my chemical laboratory and Hebei Hebei Pharmaceutical Factory collaboration from the plant products points