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目的探讨米索前列醇与缩宫素联合治疗产后出血的临床效果。方法选择2010年7月~2012年10月在本院分娩的260例产妇作为研究对象,随机分为观察组和对照组各130例,在胎儿娩出后观察组给予缩宫素20 U静脉滴注,米索前列醇400μg直肠给药,对照组单纯使用缩宫素20 U静脉滴注,观察两组产妇的第三产程时间、产后2 h出血量及产后24 h出血量。结果观察组产妇的第三产程时间明显短于对照组,产后2 h出血量、产后24 h出血量明显少于对照组,两组比较差异具有统计学意义(P<0.05)。结论米索前列醇与缩宫素联合应用可以有效减少产后出血量,并且可以缩短第三产程时间,用药简便、安全可靠,值得临床上进一步推广使用。
Objective To investigate the clinical effect of misoprostol combined with oxytocin in the treatment of postpartum hemorrhage. Methods From July 2010 to October 2012 in our hospital delivery of 260 cases of maternal as the research object, were randomly divided into observation group and control group of 130 cases, after the delivery of the fetus observation group was given oxytocin 20 U intravenous infusion , Misoprostol 400μg rectum, the control group simply using oxytocin 20 U intravenous infusion, observation of the two groups of maternal third stage of labor time, 2 h postpartum hemorrhage and 24 h postpartum hemorrhage. Results The duration of the third stage of labor in the observation group was significantly shorter than that in the control group. The amount of bleeding at 2 h postpartum and the amount of bleeding at 24 h postpartum were significantly less than those in the control group. The differences between the two groups were statistically significant (P <0.05). Conclusion The combination of misoprostol and oxytocin can effectively reduce the amount of postpartum hemorrhage, and can shorten the time of the third stage of labor. The medicine is simple, safe and reliable, which is worth further promotion in clinic.