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目的研究早期使用β-受体阻滞剂对急性心肌梗死患者心率变异的影响。方法44例急性心肌梗死患者入院后随机分为β-受体阻滞剂治疗组(18例)和对照组(26例)。治疗组于即刻给予氨酰心安(12.5～25mg/天)或美多心安(25～50mg/天),余两组治疗相同。入院后10～14天行24小时动态心电图检查,分析时域指标SNDDSDANNrMSSDPNN50、散点图指标VLI、VAI的变化。用配对t检验进行统计学处理。结果早期使用小剂量β-受体阻滞剂可使急性心肌梗死患者的心率变异的时域指标、散点图指标均有显著增加。进一步研究发现,这种改善作用在前壁与下壁急性心肌梗死之间无显著性差异。结论对急性心肌梗死患者早期使用β-受体阻滞剂可显著改善患者的心率变异,这种作用在前壁心肌梗死与下壁心肌梗死之间无显著性差异。
Objective To study the effect of early use of β-blocker on heart rate variability in patients with acute myocardial infarction. Methods Forty-four patients with acute myocardial infarction were randomly divided into β-blocker treatment group (n = 18) and control group (n = 26). Patients in the treatment group were treated with atenolol (12.5 ~ 25mg / day) or metoprolol (25 ~ 50mg / day) immediately after treatment. The remaining two groups were treated equally. After admission 10 to 14 days 24-hour dynamic electrocardiogram examination, analysis of the time domain index SNDDSDANNrMSSDPNN50, scatter plot indicators VLI, VAI changes. Paired t-test was used for statistical analysis. Results The early use of low-dose β-blockers in heart rate variability in patients with acute myocardial infarction time domain index, scatter plot indicators were significantly increased. Further study found that this improvement in the anterior wall and inferior wall acute myocardial infarction no significant difference. Conclusion The early use of β-blockers in patients with acute myocardial infarction can significantly improve the patient’s heart rate variability, this effect was no significant difference between anterior myocardial infarction and inferior myocardial infarction.