论文部分内容阅读
目的:探讨胰岛素强化治疗方案对妊娠期糖尿病(GDM)患者及胎儿的影响。方法:将70例妊娠期糖尿病患者按照随机数字表法分为2组,其中对照组35例用预混人胰岛素类进行常规治疗;观察组35例每天速效胰岛素3次注射加基础胰岛素1次注射进行强化治疗;对比分析两组患者治疗后血糖控制水平、胰岛素抵抗(HOMA-IR)程度、胰岛素分泌指数(HOMA-β)变化、妊娠合并症及新生儿合并症的发生率等。结果:观察组的患者血糖控制效果更佳,显著降低母婴并发症(P<0.01),胰岛素抵抗程度与胰岛素分泌功能均有所改善(P<0.05)。结论:胰岛素强化治疗妊娠期糖尿病可以减少母婴并发症的同时,可以在一定程度上改善患者的胰岛功能水平。
Objective: To investigate the effect of intensive insulin therapy on gestational diabetes mellitus (GDM) and fetus. Methods: Seventy patients with gestational diabetes mellitus were divided into two groups according to the random number table. Among them, 35 cases in the control group were treated with pre-mixed insulin, and 35 cases in observation group were injected with 3 times daily rapid-acting insulin and 1 case with basal insulin The levels of HOMA-IR, HOMA-β, pregnancy complications and neonatal complications were compared between the two groups after treatment. Results: The patients in the observation group had better blood sugar control effect, significantly reduced the complications of mother and infant (P <0.01), and improved the degree of insulin resistance and insulin secretion (P <0.05). Conclusion: Intensive insulin therapy of gestational diabetes mellitus can reduce maternal and infant complications, and can improve the level of pancreatic islet function to a certain extent.