蛇毒溶栓素经~(125)I标记后从大鼠尾静脉注入,脏器分布主要是肾、肺、肝、脾,而脑中浓度较低。血液和各脏器放射性标记物浓度高峰均在1h内出现。大部份标记物从尿中排出,高峰在给药后1h。粪排出量远比尿少,高峰在给药后4h。直至48h,各脏器仍可测出残留放射性标记物。 The venom thrombolytic factor was injected into the tail vein of the rat after labeling with ~ (125) I. The distribution of organs was mainly kidney, lung, liver and spleen, while the brain concentration was lower. The peak concentrations of radioactive markers in blood and various organs appeared within 1 h. Most of the markers were excreted from the urine, peaked at 1 h after dosing. Excretion of urine far less than urine, the peak 4h after administration. Until 48h, each organ can still detect residual radioactive markers.