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应用免疫组化ＡＢＣ法，对１００例乳腺癌的表皮生长因子受体（ＥＧＦＲ）、ＥＲ及ＰｇＲ进行了检测。结果显示：ＥＧＦＲ阳性３４例，ＥＲ阳性６ｌ例，ＰｇＲ阳性３０例。其中３项均阳性者５例，ＥＲ与ＥＧＦＲ，ＰｇＲ与ＥＧＦＲ阳性者各８例，结果说明乳腺癌中ＥＧＦＲ阳性率高于良性乳腺肿瘤，差异显著（Ｐ＜０．０１）。ＥＧＦＲ在乳腺癌中的表达与ＥＲ表达呈显著负相关关系（Ｐ＜０．０５）；ＥＲ的表达与患者的绝经状态显著相关（Ｐ＜０．０５）；不同病理组织学类型的乳腺癌ＥＧＦＲ阳性率存在一定差异；而ＥＲ是乳腺癌高分化、预后好的标志，ＥＧＦＲ则相反（Ｐ＜０．０１）。
Immunohistochemical ABC method was used to detect epidermal growth factor receptor (EGFR), ER and PgR in 100 cases of breast cancer. The results showed that 34 cases were positive for EGFR, 61 cases were positive for ER, and 30 cases were positive for PgR. Among them, 5 cases were all positive, 8 cases were ER and EGFR, 8 cases were positive for PgR and EGFR. The results showed that the positive rate of EGFR in breast cancer was higher than that in benign breast tumors (P<0.01). The expression of EGFR in breast cancer was negatively correlated with the expression of ER (P<0.05); the expression of ER was significantly associated with the menopausal status of patients (P<0.05); different histopathological types of breast cancer EGFR There is a certain difference in the positive rate; ER is a good marker for breast cancer with high differentiation and good prognosis, but EGFR is the opposite (P<0.01).