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肾移植术在国内外器官移植中始终处于首位,是目前临床上最常见的器官移植术,在救治了许多患者的同时,其远期的并发症也不容忽视。术后骨代谢紊乱的发病率越来越高,可能与术后免疫抑制剂的使用有关。该文分别从免疫抑制剂影响患者的钙代谢、破骨细胞和成骨细胞的正常生理功能、激素分泌水平等方面进行阐述,最后发现术后免疫抑制剂的使用与术后骨代谢关系密切,改良免疫抑制剂能够提高患者的生存质量。
Renal transplantation has always been in the first place in domestic and foreign organ transplantation. It is the most common organ transplantation in clinic at present, and its long-term complications can not be neglected while many patients are being treated. Postoperative morbidity of bone metabolism disorders is increasing, may be related to the use of postoperative immunosuppressive agents. In this paper, the effects of immunosuppressive agents on calcium metabolism, the normal physiological function of osteoclasts and osteoblasts, the level of hormone secretion and so on are described respectively. Finally, the use of postoperative immunosuppressive agents is closely related to postoperative bone metabolism, Improved immunosuppressive agents can improve patients’ quality of life.