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目的探讨应用电化学发光法测定血浆D-D二聚体在弥散性血管内凝血(DIC)中的临床应用意义。方法选取20例DIC患者(观察组)、20例疑似DIC患者(对照1组)、20例正常人(对照2组),均应用电化学发光法进行血浆D-D二聚体水平的测定,同时对20例疑似DIC者进行D-D二聚体动态检测;对所有数据进行统计分析、比较。结果血浆D-D二聚体水平在观察组、对照1组和对照2组分别为(2951.1±1683.8)μg/L、(532.3±360.6)μg/L和(182.5±90.2)μg/L,3组比较差异有统计学意义(P<0.01);且观察组、对照1组较对照2组均明显增高(P均<0.01),观察组较对照1组明显增高(P<0.01)。对疑似DIC组实施动态检测后,有9例被确诊为DIC,另11例排除怀疑。结论电化学发光法测定血浆D-D二聚体水平对临床DIC的诊断具有一定的参考价值,可作为早期DIC诊断指标之一。
Objective To investigate the clinical significance of detecting plasma D-D dimer in disseminated intravascular coagulation (DIC) by electrochemiluminescence. Methods 20 patients with DIC (observation group), 20 patients with suspected DIC (control group 1) and 20 normal subjects (control group 2) were selected for the determination of plasma DD dimer levels by electrochemiluminescence 20 cases of suspected DIC DD dimer dynamic detection; statistical analysis of all data, compared. Results The level of plasma DD dimer was (2951.1 ± 1683.8) μg / L, (532.3 ± 360.6) μg / L and (182.5 ± 90.2) μg / L respectively in the observation group, (P <0.01). The observation group and control group 1 were significantly higher than those of control group 2 (all P <0.01), and the observation group was significantly higher than that of control group 1 (P <0.01). After the dynamic test on the suspected DIC group, 9 cases were diagnosed with DIC, and the other 11 cases were excluded. Conclusion The determination of plasma D-D dimer by electrochemiluminescence has some reference value for the diagnosis of clinical DIC, which can be used as one of the diagnostic indicators for early DIC.