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目的探讨“三合一”疗法治疗慢性乙型肝炎(简称慢乙肝)的疗效。方法选择2002年7月~2005年6月在秦皇岛市第三医院住院或门诊就诊入组的慢乙肝患者172例作为观察对象,随机分为两组,治疗组93例,给予“三合一”疗法,包括:①内服系列中药,“肝饮Ⅰ号”治疗4周,后改用“肝饮Ⅱ号”继续治疗8周,总共12周为1个疗程,随访12周。②中药膏剂穴位贴敷,共选9个穴位,每个穴位适量贴敷“扶正拔毒膏”。③理疗离子导入。对照组79例,给予普通干扰素(IFN-α)治疗。两组病例均不用其他免疫调节药及抗病毒药物,且西医基础治疗相同。结果疗程结束时(治疗组12周,对照组24周),两组疗效比较,治疗组93例,显效(完全应答)15例(16.12%),有效(部分应答)32例(34.41%),总有效率(应答率)50.53%;对照组79例,显效(完全应答)9例(11.39%),有效(部分应答)26例(32.91%),总有效率(应答率)44.30%。经统计学处理,差异无统计学意义。结论“三合一”疗法治疗慢乙肝在改善肝功能、抑制乙肝病毒(HBV)复制方面确有较好疗效。
Objective To investigate the efficacy of “triple therapy” in the treatment of chronic hepatitis B (referred to as chronic hepatitis B). Methods From July 2002 to June 2005, 172 patients with chronic hepatitis B who were hospitalized or outpatient in the Third Hospital of Qinhuangdao City were randomly divided into two groups. The treatment group was given 93 patients with “ ”Treatment, including: ① oral administration of traditional Chinese medicine,“ liver drink Ⅰ ”for 4 weeks, then switch to“ liver Yin Ⅱ ”to continue treatment for 8 weeks, a total of 12 weeks for a course of treatment, followed up for 12 weeks . ② Chinese medicine paste acupoint sticking, a total of nine points selected, each acupuncture points affixed “Fuzheng pulling poison cream.” ③ physiotherapy ion introduction. The control group, 79 cases, given normal interferon (IFN-α) treatment. Two groups of patients without other immunomodulatory drugs and antiviral drugs, and the same basis of Western medicine treatment. Results In the treatment group, 93 cases were markedly effective (complete response), 32 cases (34.41%) were effective (partial response), 15 (16.12% The total effective rate (response rate) was 50.53%. In the control group, 79 patients were markedly effective (complete response), 9 (11.39%) were effective (partial response), 26 (32.91%) were effective (partial response), and the total effective rate (response rate) was 44.30%. After statistical analysis, the difference was not statistically significant. Conclusion “Triple therapy” treatment of chronic hepatitis B in improving liver function, inhibition of hepatitis B virus (HBV) replication has a good effect.