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目的:探讨高效抗反转录病毒治疗(HAART)联合中成药唐草片治疗HIV感染的有效性和安全性。方法:入选118例HIV感染者在我院进行抗病毒治疗患者,加用唐草片后每3月随访一次,记录其临床症状及实验室检查结果。结果:治疗前患者CD4 T细胞计数为223(136~379)个/μl,经过(11.8±3.7)月的联合治疗后患者CD4 T细胞计数上升至320(206~469)个/μl(P<0.000 1)。其中刚开始治疗患者采用联合治疗后1年内CD4 T细胞计数上升幅度和单用HAART无显著差异。23.7%(28/118)的患者在随访过程中出现不良反应,均为1、2级,经对症治疗后均改善。结论:HAART联合唐草片治疗HIV感染具有较好的免疫学治疗效果及安全性。
Objective: To investigate the effectiveness and safety of HAART in combination with proprietary Chinese medicine Tangcao Tablet in the treatment of HIV infection. Methods: A total of 118 cases of HIV-infected patients were enrolled in our hospital for antiviral therapy. Follow-up was performed every 3 months after adding Tangshao tablets and the clinical symptoms and laboratory test results were recorded. Results: Before treatment, the number of CD4 T cells was 223 (136 ~ 379) / μl, and the CD4 T cell count increased to 320 (206 ~ 469) / μl after 11.8 ± 3.7 months of treatment (P < 0.000 1). Among them, the increase rate of CD4 T cell counts within 1 year after the start of treatment with combination therapy was not significantly different from HAART alone. In the follow-up period, 23.7% (28/118) of patients showed adverse reactions, both of which were grade 1 and 2, and were improved after symptomatic treatment. Conclusion: HAART combined with Tangcao Tablet in the treatment of HIV infection has better immunological efficacy and safety.