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实验表明13-顺-维甲酸(下简称维甲酸)能够使某些白血病细胞分化为稳定的粒细胞。本研究应用维甲酸治疗4例MDS病人和4例难治性ANLL病人。开始用量40mg/日连用3日,随后增加到80mg/日连用3日,能耐受者可增加到120mg/日(40mg3次/日)。以血色素,中性白细胞绝对值和血小板计数在不输血情况下持续正常,骨髓细胞结构,细胞分化及形态恢复正常为血液学和骨髓的有效指标。 MDS病人平均治疗5-25个月均无效。4例
Experiments show that 13-cis-retinoic acid (hereinafter referred to retinoic acid) can make some leukemia cells differentiate into stable granulocytes. In this study, retinoic acid treatment of 4 patients with MDS and 4 patients with refractory ANLL. Start dosage 40mg / day for 3 days, then increased to 80mg / day for 3 days, can tolerate increased to 120mg / day (40mg3 times / day). With hemoglobin, neutrophil absolute value and platelet count continued normal without blood transfusion, bone marrow cell structure, cell differentiation and morphological recovery of normal hematology and bone marrow effective indicators. The average treatment of MDS patients 5-25 months are invalid. 4 cases