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目的观察信号转导与转录活化因子3(STAT3)在老年子宫内膜癌组织和子宫肌瘤患者中的表达情况。方法收集西平县人民医院2010年2月至2014年2月收治的48例老年子宫内膜癌患者(子宫内膜癌组)和30例子宫肌瘤患者(子宫肌瘤组),全部患者均由手术切除组织标本后经病理检查确诊,对两组患者标本中的STAT3、孕激素受体(PR)、雌激素受体(ER)的阳性表达情况进行观察,并分析STAT3、PR、ER在老年子宫内膜癌病理表达情况。结果子宫内膜癌组患者标本中的STAT3的阳性表达率高于子宫肌瘤组(P<0.01),而PR、ER的阳性表达率低于子宫肌瘤组(P<0.01),在子宫内膜癌患者标本中随着临床分级及组织学分级的增加,STAT3的阳性表达水平逐渐升高,而PR和ER的阳性表达水平则显著下降。结论 STAT3阳性表达水平能够在一定程度上反映老年子宫内膜癌的发生发展过程,可用于子宫内膜癌的临床治疗指导和预后评估。
Objective To observe the expression of signal transducer and activator of transcription 3 (STAT3) in elderly patients with endometrial carcinoma and uterine fibroids. Methods 48 cases of elderly patients with endometrial cancer (endometrial cancer) and 30 cases of uterine fibroids (patients with uterine fibroids) were collected from Xiping County People’s Hospital from February 2010 to February 2014. All patients Surgical resection of the tissue specimens confirmed by pathological examination of the two groups of patients specimens STAT3, progesterone receptor (PR), estrogen receptor (ER) positive expression was observed, and STAT3, PR, ER in the elderly Endometrial cancer pathological expression. Results The positive rate of STAT3 in endometrial carcinoma group was higher than that in uterine fibroid group (P <0.01), while the positive rate of PR and ER was lower in uterine fibroid group (P <0.01) With the increase of clinical grade and histological grade, the positive expression level of STAT3 gradually increased while the positive expression level of PR and ER significantly decreased in the patients with cancer. Conclusion The positive STAT3 expression can reflect the development and progression of senile endometrial cancer to a certain extent and can be used for clinical treatment guidance and prognosis evaluation of endometrial cancer.