急性高原病(acute mountain sickness,AMS)是指由平原快速进入高原(或由低海拔地区进入高海拔地区)时,因机体对低氧环境的适应能力不全或失调而发生的综合征。低气压和缺氧是引发AMS的最主要或最关键的因素,缺氧是上调血管内皮生长因子(vascular endothelial growth factor,VEGF)表达的最主要的因素,近年来研究发现VEGF在AMS发生中可能发挥重要作用,迄今有关VEGF与AMS的研究主要集中在AMS发病后体内VEGF的变化观察,而有关AMS患者在平原状态下体内 Acute mountain sickness (AMS) refers to the syndrome that occurs when the plains rapidly enter the plateau (or enter the high altitude areas from low altitude areas) due to the body’s ability to adapt to the hypoxic environment. Hypoxia and hypoxia are the most important or key factors that lead to AMS. Hypoxia is the most important factor that up-regulates the expression of vascular endothelial growth factor (VEGF). In recent years, it has been found that VEGF may be involved in the development of AMS Play an important role, so far the study of VEGF and AMS focused on the incidence of AMS in vivo changes in the observation of VEGF, and AMS patients in plain state in vivo