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用紫外分光光度法，测定１０名男性健康志愿受试者单剂量交叉口服１ｇ扑热息痛片和扑热息痛咀嚼片后的血药浓度，以扑热息痛片为对照品，计算扑热息痛咀嚼片的相对生物利用度（Ｆ）。ＭＣＰＫＰ计算机程序拟合和统计学分析。结果表明，两制剂的Ｃｍａｘ、Ｔｍａｘ、ＡＵＣ等药动学参数无显著差异（Ｐ＞００５），扑热息痛咀嚼片的Ｆ值为（１１４６５±１６１７）％。
The plasma concentrations of 1 g paracetamol tablets and paracetamol chewable tablets in 10 male healthy volunteers were determined by ultraviolet spectrophotometry. The relative bioavailability of paracetamol chewable tablets was calculated by F ). MCPKP computer program fitting and statistical analysis. The results showed that there was no significant difference in the pharmacokinetic parameters (Cmax, Tmax, AUC, etc.) between the two preparations (P> 005). The F value of paracetamol chewable tablets was (11465 ± 1617)%.