奈诺沙星是一种新型无氟喹诺酮类药物,对革兰阳性菌和革兰阴性菌、厌氧菌及非典型病原体,包括多重耐药的肺炎链球菌和甲氧西林耐药金葡菌均有抗菌作用。本研究采用一种新型体外PK/PD模型模拟空腹单剂(100 mg、250mg、500 mg、750 mg)和多剂(125 mg,每6小时1次和500mg,每日1次)口服苹果酸奈诺沙星的药动学过程,观察不同给药剂量下对2株青霉素敏感肺炎链球菌(PSSP,MIC分 Ninufloxacin is a new class of fluorine-free quinolone drugs against Gram-positive and Gram-negative bacteria, anaerobic bacteria and atypical pathogens, including multi-drug resistant Streptococcus pneumoniae and methicillin-resistant Staphylococcus aureus Have antibacterial effect. In this study, a novel in vitro PK / PD model was used to simulate the effects of fasting single dose (100 mg, 250 mg, 500 mg, 750 mg) and multiple doses (125 mg once every 6 hours and 500 mg once daily) The pharmacokinetics of nelfoxacin was observed in two different doses of penicillin-susceptible Streptococcus pneumoniae (PSSP, MIC score