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金属材料是医学植介入器件的主要应用材料之一,由于其具有离子溶出与生物惰性等缺点,因此如何提高植体表面的生物相容性与组织适配性成为金属生物材料领域的研究热点。在器件表面制备微纳结构,通过接触诱导机制对细胞及组织进行调控是改善金属植介入器件表面生物功能的重要研究方向之一。本文综合评述了金属植介入器件表面各种图案化微纳结构的制备技术与应用进展,并综述了接触诱导作用对成骨与血管内皮细胞、组织生长行为的调控以及对干细胞定向分化诱导等领域的研究进展。
Metallic materials are one of the main materials used in implanting medical devices. Due to their disadvantages such as ion dissolution and bio-inertness, how to improve the biocompatibility and tissue compatibility of implant surfaces has become a hot research topic in the field of metal biomaterials. It is one of the important research directions to improve the biological function of the surface of metal implanted devices by preparing the micro / nano structure on the surface of the device and regulating the cells and tissues through the contact induction mechanism. This review summarizes the preparation technology and application progress of various patterned micro / nano structures on the surface of implantable devices and summarizes the effects of contact induction on the regulation of osteoblast and vascular endothelial cells, tissue growth and induction of stem cell differentiation Research progress.