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本文研究了自杀基因与细胞因子基因联合应用治疗结肠癌肝转移的效果。用自杀基因(HSV-tk)治疗肝转移肿瘤,肿瘤有明显消退,但是所有的实验动物均有肿瘤复发。联合应用腺病毒载体包装的白介素Ⅱ(mIL-2)基因疗法有明显的抗肿瘤效果,然而这种抗肿瘤能力逐渐减退。最后,所有的实验动物都死于肿瘤复发或远处转移。本实验还证明了粒细胞巨噬细胞集落刺激
This article studied the effect of combined use of suicide gene and cytokine gene therapy for liver metastasis of colon cancer. Liver metastatic tumors were treated with the suicide gene (HSV-tk). The tumors were significantly regressed, but all experimental animals had tumor recurrence. The interleukin-II (mIL-2) gene therapy packaged with an adenoviral vector has a significant anti-tumor effect, but this anti-tumor ability gradually declines. Finally, all experimental animals died of tumor recurrence or distant metastases. This experiment also demonstrated granulocyte macrophage colony stimulation