粘膜免疫是机体防御系统的主要成分。致病性细菌侵入机体后,首先遭遇到天然免疫的抵抗,随后产生获得性免疫,两者共同执行机体的防御功能,消灭入侵细菌。最近的研究表明上皮细胞对细菌感染有重要的免疫调节作用,在天然免疫与获得性免疫防御机制中起重要作用。本文重点介绍肠上皮细胞在天然免疫中的作用。 Mucosal immunity is the main component of the body’s defense system. Pathogenic bacteria invade the body, the first encounter natural immune resistance, followed by acquired immunity, both jointly enforce the body’s defense function, the elimination of invasive bacteria. Recent studies have shown that epithelial cells have an important immunomodulatory effect on bacterial infections and play an important role in innate and adaptive immune defense mechanisms. This article focuses on the role of intestinal epithelial cells in innate immunity.