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目的利用因子分析方法研究高血压住院患者治疗强度与降压效果的关系,为高血压病的降压治疗提供参考,也为开发和利用药品处方数据库进行科学研究提供一种方法。方法调用本院用药数据库和住院病史,提取高血压住院患者用药记录和住院期间的收缩压和舒张压等信息,用因子分析法计算患者治疗强度,并用方差分析法比较不同治疗强度的降压效果。结果住院高血压患者的血压下降值随治疗强度增加而增加。结论利用临床诊疗信息和因子分析法研究患者治疗强度与降压效果的关系其结果有参考价值,这种方法在临床药学研究中的应用值得重视。
Objective To study the relationship between treatment intensity and antihypertensive efficacy in hospitalized hypertensive patients by factor analysis and to provide reference for antihypertensive treatment of hypertension and to provide a method for the scientific research on the development and utilization of drug prescription database. Methods The hospital medication database and hospitalization history were used to extract information on the medication records of patients with hypertension and systolic and diastolic blood pressure during hospitalization. The treatment intensity was calculated by factor analysis and the antihypertensive effects of different treatment intensities were compared by analysis of variance . Results The decrease of blood pressure in hospitalized hypertensive patients increased with the increase of treatment intensity. Conclusion The clinical therapeutic information and factor analysis method to study the relationship between treatment intensity and antihypertensive efficacy of the results of reference, the application of this method in clinical pharmacy deserves attention.