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目的研究分析人表皮生长因子受体-2(Her-2)在胃癌及正常胃组织中的表达以及与临床病理参数的关系,分析胃癌中Her-2表达的临床意义,为胃癌的靶向治疗奠定理论基础。方法应用免疫组化法检测在78例原发胃癌及39例正常胃组织中Her-2基因的表达。结果在胃癌组织中Her-2过表达率为23.08%,正常胃组织中Her-2过表达率为0。胃癌中,Her-2的表达与胃癌的位置、Lauren分型相关(P<0.05),与组织学分化程度无相关性(P>0.05)。结论 Her-2在胃癌中的表达可能与胃癌的预后有密切关系,检测Her-2蛋白,可能使患者从辅助靶向治疗中获益。
Objective To investigate the expression of Her-2 in gastric cancer and normal gastric tissue and its relationship with clinicopathological parameters, and to analyze the clinical significance of Her-2 expression in gastric cancer and to provide targeted therapy for gastric cancer Lay the theoretical foundation. Methods The expression of Her-2 gene in 78 cases of primary gastric cancer and 39 cases of normal gastric tissue was detected by immunohistochemistry. Results The overexpression of Her-2 in gastric cancer tissues was 23.08%, while the overexpression of Her-2 in normal gastric tissues was 0.78. In gastric cancer, the expression of Her-2 was correlated with the location of gastric cancer and Lauren classification (P <0.05), but not with the degree of histological differentiation (P> 0.05). Conclusion The expression of Her-2 in gastric cancer may be closely related to the prognosis of gastric cancer. The detection of Her-2 protein may benefit patients from adjuvant targeted therapy.