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目的探讨T2DM患者大血管病变与踝臂脉搏波传导速度(baPWV)的相关性。方法选取T2DM患者284例,根据是否患有T2DM合并大血管病变分为T2DM合并大血管病变组139例和单纯T2DM组145例。检测两组baPWV和其他生化指标。结果两组baPWV、高敏C反应蛋白(hsC-RP)和年龄比较,差异有统计学意义(P<0.05)。相关性分析显示,baPWV异常与DBP、hsC-RP和年龄呈正相关。二元Logistic回归分析显示,DBP、FPG、HbA_1c、hsC-RP和年龄是T2DM合并大血管病变的影响因素,FPG和TC是危险因素。受试者工作特征(ROC)曲线下面积为0.641,当baPWV切点为18.23m/s时,其敏感性与特异性分别为83.5%和43.4%,具有一定的诊断价值。结论 T2DM大血管病变与baPWV呈一定的相关性,可能与hsC-RP的升高对baPWV的影响有关,对T2DM大血管病变具有一定的诊断价值。
Objective To investigate the relationship between macrovascular complications and ankle brachial pulse wave velocity (baPWV) in patients with T2DM. Methods Totally 284 T2DM patients were divided into two groups: 139 patients with T2DM complicated with macroangiopathy and 145 patients with T2DM only according to whether they had T2DM complicated with macrovascular complications. Two groups of baPWV and other biochemical indexes were detected. Results The differences of baPWV, hsC-RP and age between the two groups were statistically significant (P <0.05). Correlation analysis showed that the abnormality of baPWV was positively correlated with DBP, hsC-RP and age. Binary Logistic regression analysis showed that DBP, FPG, HbA_1c, hsC-RP and age were the influencing factors of macrovascular complications in T2DM. FPG and TC were risk factors. The area under the receiver operating characteristic (ROC) curve was 0.641. When baPWV was 18.23 m / s, its sensitivity and specificity were 83.5% and 43.4% respectively, which had a certain diagnostic value. Conclusions There is a correlation between large vessel disease and baPWV in T2DM, which may be related to the effect of hsC-RP on baPWV. It may be of value in the diagnosis of T2DM.