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近年来由于心肌生理、生化及血液动力学等方面的研究进展及由于新的床边监护技术的开展,使心力衰竭(以后简称为心衰)时血管扩张剂的应用日益广泛。本文对血管扩张剂在心衰中临床应用的一些问题结合部分资料报告作一概述。临床应用的病理生理学基础心脏泵出功能的生理学基础正常心脏有良好的适应力,其工作力能充分适应身体变化的需要。在各种生理情况下,身体组织灌注所需要增加的血流量主要从心排出量的增高而得到补充。Mason指出心脏功能状态的调节取决于:①前负荷;②心肌收缩力;③后负荷;④心率;⑤心室收缩协调性等五个因素。前负荷是指心室起始容量由心室舒张末期容量或压力表示。生理性限度内心脏舒张期容
In recent years due to myocardial physiology, biochemistry and hemodynamics and other aspects of the research progress and as a result of the new bedside monitoring technology to make heart failure (hereinafter referred to as heart failure) vasodilator increasingly widespread. In this paper, some of the clinical application of vasodilators in heart failure combined with some of the data report to give an overview. The Basics of Pathophysiology for Clinical Applications The Physiological Basis of Heart Pumpout Normal hearts have a good fitness and their work force can fully adapt to the needs of the body. In all physiological conditions, increased blood flow required for bodily tissue perfusion is supplemented primarily by increased cardiac output. Mason pointed out that the regulation of cardiac function depends on: ① preload; ② myocardial contractility; ③ afterload; ④ heart rate; ⑤ ventricular contraction and coordination of five factors. Preload refers to the initial capacity of ventricular end-diastolic capacity or pressure that. Physiological limits within the diastolic volume