钙化性主动脉瓣狭窄的发病率随年龄增加而上升 ,是主动脉瓣置换术的最常见原因。自 1 90 4年 Monckeburg描述该病后 ,已提出了不少其钙化形成的学说。机械磨损学说强调瓣膜胶原纤维“磨损和撕裂”继而导致钙化 ;譬如通过先天性二尖瓣形成的异常血流 ,增加瓣膜的磨损撕裂使其易 The incidence of calcific aortic stenosis increases with age and is the most common cause of aortic valve replacement. Since the description of the disease by Monckeburg in 1994, many theories of calcification have been proposed. The mechanistic wear-out doctrine emphasizes the “wear and tear” of the valve collagen fibers which in turn leads to calcification; for example, abnormal blood flow through the congenital mitral valve, which increases the valve’s wear and tear