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目的探讨卵巢上皮性癌中PTEN表达及其意义。方法 2009年1月至2010年6月收治的卵巢上皮性癌89例,选取同期良性卵巢肿瘤90例,正常卵巢组织90例,采用S-P免疫组化法进行PTEN检测。结果正常卵巢组、良性卵巢肿瘤组与卵巢上皮性癌组PTEN阳性率比较P<0.05有显著差异性。卵巢上皮性癌临床分期Ⅰ-Ⅱ期与Ⅲ-Ⅳ期PTEN阳性率比较P<0.05有显著差异性。病理分级G1~G2与G3PTEN阳性率比较P<0.05有显著差异性。结论 PTEN阳性表达及表达缺失对于评价卵巢上皮性癌卵巢的恶性程度、转移及预后具有显著临床价值。
Objective To investigate the expression of PTEN in ovarian epithelial carcinoma and its significance. Methods 89 patients with epithelial ovarian cancer who were treated from January 2009 to June 2010 were enrolled. Totally 90 benign ovarian tumors and 90 normal ovarian tissues were selected for the detection of PTEN by S-P immunohistochemistry. Results The positive rates of PTEN in normal ovarian group, benign ovarian tumor group and epithelial ovarian cancer group were significantly different (P <0.05). Ovarian epithelial cancer clinical stage Ⅰ-Ⅱ and Ⅲ-Ⅳ PTEN positive rate was significantly different P <0.05. Pathological grading G1 ~ G2 and G3PTEN positive rate compared P <0.05 significant difference. Conclusion The positive expression of PTEN and the lack of expression of ovarian epithelial ovarian cancer ovarian cancer evaluation of the degree of malignancy, metastasis and prognosis of significant clinical value.