作者认为由于缺乏可靠的和重现性好的方法测定体液中青蒿素及其衍生物的浓度,对目前已有的药物动力学资料应持谨慎态度。现有资料表明青蒿素类化合物吸收良好,在体内迅速水解为有效代谢物双氢青蒿素,并迅速排除。青蒿酯钠:静脉注射后数分钟内 The authors conclude that caution should be exercised over current pharmacokinetic data due to the lack of reliable and reproducible methods for the determination of artemisinin and its derivatives in body fluids. Available data show that artemisinin compounds absorb well and rapidly hydrolyze dihydroxyartenin, the active metabolite, in the body and are quickly eliminated. Artesunate sodium: within minutes after intravenous injection