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目的:探讨酚妥拉明联合西咪替丁辅助治疗小儿毛细支气管炎的临床疗效。方法:200例毛细支气管炎患儿随机分为治疗A组、治疗B组和对照组,3组均采用相同的综合基础治疗:利巴韦林10～15 mg/(kg.d)及吸氧、止咳、镇静等。治疗A组在上述治疗基础上加用酚妥拉明0.1～0.3 mg/kg,加入5%葡萄糖注射液20～30 ml静脉滴注,3～5滴/min,每天1～2次,一般连用3～5天。治疗B组,在A组的基础上加用西咪替丁注射液10～15 mg/(kg.d),加入10%葡萄糖注射液30～50 ml静脉滴注,1次/天,疗程5～7天。观察3组症状、体征持续时间及住院时间等进行对照评价。结果:咳嗽消失、哮鸣音消失、湿啰音消失及平均住院日,3组比较,差异均有统计学意义(P<0.05或P<0.01);治愈率比较,3组差异也均有统计学意义(P<0.05或P<0.01)。结论:酚妥拉明联合西咪替丁辅助治疗小儿毛细支气管炎能加快患儿咳嗽症状缓解,加快患儿肺部体征消失,从而缩短病程及提高治愈率,且安全、方便,值得临床推广应用。
Objective: To investigate the clinical efficacy of phentolamine combined with cimetidine in the treatment of children with bronchiolitis. Methods: A total of 200 children with bronchiolitis were randomly divided into treatment group A, treatment group B and control group. All the three groups were treated with the same basic treatment: ribavirin 10 ~ 15 mg / (kg.d) and oxygen , Cough, calm and so on. Treatment group A was added Phentolamine 0.1 ~ 0.3 mg / kg on the basis of the above treatment, 20 ~ 30 ml 5% glucose injection by intravenous drip, 3-5 drops / min, 1 ~ 2 times daily, 3 ~ 5 days. Group B was treated with 10-15 mg / (kg.d) of cimetidine injection on the basis of group A, 30-50 ml of 10% glucose injection was intravenously dripped once daily for 5 days ~ 7 days. 3 groups were observed symptoms, signs of duration and hospital stay for control evaluation. Results: The disappearance of cough, the disappearance of wheeze, the disappearance of wet rales and the average length of stay in the three groups were statistically significant (P <0.05 or P <0.01). The cure rates were also statistically different among the three groups Significance (P <0.05 or P <0.01). Conclusion: Phentolamine combined with cimetidine adjuvant treatment of children with bronchiolitis can accelerate the relief of cough in children, accelerate the disappearance of pulmonary signs in children, thus shortening the course of disease and improving the cure rate, and is safe and convenient, worthy of clinical application .