对脊髓灰质炎灭活疫苗(IPV)的免疫原性检测有许多方法。在一项世界卫生组织(WHO)合作研究中,10个实验室对6种三价IPV的免疫原性进行了检测。整个研究分两部分,第一部分是检测疫苗的免疫原性(体内试验),要求所有实验室采用已确立的免疫原性试验,6个实验室用欧洲药典委员会的豚鼠/小鸡试验,即不同稀释度疫苗单次免疫豚鼠或小鸡,5～6天后取血清,检测其中和 There are many ways to test the immunogenicity of poliomyelitis inactivated vaccine (IPV). In a WHO collaborative study, 10 laboratories tested the immunogenicity of six trivalent IPVs. The whole study was divided into two parts. The first part was to test the immunogenicity of the vaccine (in vivo test), all laboratories were required to have established immunogenicity tests, and six laboratories were tested with the European Pharmacopoeia Commission’s guinea pig / chick test, ie different Dilution of vaccine single immunization guinea pigs or chickens, 5 to 6 days after the serum taken to detect its neutralization