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目的探讨宫腔内人工授精(IUI)每周期授精次数与周期数对妊娠率的影响。方法分析1056例不育不孕患者共1368个IUI治疗周期,检测记录每个周期精液处理后活动精子总数及妊娠结果。根据IUI实施方式分成2组:单次IUI与双次IUI,比较两组的精子活动总数和妊娠率;纵向分析IUI的累积妊娠概率,比较各周期的妊娠率,了解IUI周期数对妊娠率的影响。结果1368个IUI周期共获得201例妊娠,总周期妊娠率是14.7%,总病例妊娠率是19.0%。单次IUI与双次IUI相比,活动精子总数分别是(18.86±9.54)和(38.60±18.21),前者明显少于后者(P<0.05);获得的妊娠率分别是10.3%和16.5%,两者有显著性差异(P<0.05)。结论(1)单次IUI妊娠率明显少于双次IUI;(2)适应于IUI治疗的不育患者,至少应进行3~4次IUI治疗,未成功者,才需考虑其他精卵结合障碍等问题,或求助于试管婴儿等其他辅助生殖技术。
Objective To investigate the effect of intrauterine insemination (IUI) fertilization frequency and cycle number on pregnancy rate. Methods A total of 1368 IUI treatment cycles were performed in 1056 cases of infertility infertility. The total sperm counts and pregnancy outcomes were recorded and recorded after each cycle of semen treatment. According to the IUI implementation, the patients were divided into two groups: single IUI and double IUI. The total number of sperm motility and pregnancy rate were compared between the two groups. The cumulative probabilities of IUI were analyzed longitudinally. The pregnancy rates of each cycle were compared. influences. Results A total of 201 pregnancies were obtained in 1368 IUI cycles, with a total cycle pregnancy rate of 14.7% and a total case pregnancy rate of 19.0%. Compared with the double IUI, the total number of active sperm was (18.86 ± 9.54) and (38.60 ± 18.21) respectively, the former was less than the latter (P <0.05). The pregnancy rates obtained were 10.3% and 16.5% , There was a significant difference between the two (P <0.05). Conclusions (1) The pregnancy rate of single IUI is obviously less than that of double IUI. (2) Infertility patients who adapt to IUI treatment should be treated with IUI therapy for at least 3 to 4 times. If they are not successful, they need to consider other sperm-egg binding disorders Such as IVF or other assisted reproductive technologies.