防突变浓度是指防止耐药突变菌株被选择性富集扩增所需的最低抗菌药物浓度。防突变浓度与MIC的浓度范围为突变选择窗。只有当血清或组织液药物浓度处于突变选择窗内时 ,才出现耐药突变菌株的选择性富集扩增 ,从而产生耐药。这一理论为有效抑制细菌耐药及制定抗菌药物应用策略提供了新的思路和参考依据。 Anti-mutation concentration refers to the lowest concentration of antimicrobials required to prevent the drug-resistant mutant strains from being selectively enriched for amplification. The concentrations of anti-mutation concentration and MIC are mutation selection window. Only when the concentration of serum or tissue fluid drug is in the window of mutation selection, selective enrichment and amplification of drug-resistant mutant strains appear, resulting in drug resistance. This theory provides a new idea and reference for the effective inhibition of bacterial resistance and the development of antimicrobial drug application strategies.