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以五倍止泻胶囊 1.0 g/ kg、2 .0 g/ kg灌胃小鼠 ,观察五倍止泻胶囊对小鼠肠管推进运动、腹泻、游泳及镇痛的影响。结果显示五倍止泻胶囊对小鼠肠管推进运动有明显的抑制作用 (P<0 .0 0 1) ;对大黄所致腹泻有明显的止泻作用 (P<0 .0 1) ;对大黄所致“脾虚”小鼠游泳时间的缩短有明显的增加作用 (P<0 .0 1) ;对醋酸所致小鼠扭体次数增加有明显的减少作用 (P<0 .0 5 ) ;表明五倍止泻胶囊确有益气健脾、固肠止泻之功效。
The rats were intragastrically administered with five times the antidiarrheal capsules 1.0 g/kg and 2.0 g/kg, and the effects of five-fold antidiarrheal capsules on bowel movement, diarrhea, swimming, and analgesia were observed. The results showed that the five-fold Zhixie capsule had a significant inhibitory effect on the advancing movement of the intestine in mice (P<0.01); it had a significant antidiarrheal effect on rhubarb-induced diarrhea (P<0.01); The shortening of swimming time in mice with “spleen deficiency” had a significant increase (P < 0.01) and a significant decrease in the number of writhing induced by acetic acid (P <0. 05); Five times antidiarrheal capsules are indeed beneficial to qi and spleen, colon fixed diarrhea effect.