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目的:分析影响原发性癫痫患者发生认知功能障碍的危险因素。方法:采用韦氏成人智力量表(WAIS-RC)对研究组100例原发性癫痫患者与对照组50例健康体检者进行认知功能测验,同时对影响认知功能的相关因素进行单因素分析与多元线性逐步回归分析。结果:研究组患者认知功能测验中知识、领悟、算术等11个分测量指标得分均显著低于对照组(P<0.001);研究组言语智商(VIQ)、操作智商(PIQ)及全量表智商(FIQ)得分显著低于对照组(P<0.001);相关性分析结果显示FIQ与学历、抗癫痫药物数量、发作时间及病程显著相关(R=0.611),VIQ与学历、抗癫痫药物数量显著相关(R=0.619),PIQ与发作时间、年龄、抗癫痫药物数量及学历显著相关(R=0.571)。结论:原发性癫痫患者认知功能障碍的发生与学历、年龄、病程、抗癫痫药物数量、发作持续时间等因素显著相关。
Objective: To analyze the risk factors of cognitive dysfunction in patients with primary epilepsy. Methods: Fifty patients with primary epilepsy in the study group and 50 healthy subjects in the control group were tested for cognitive function using the WAIS-RC, and the related factors affecting cognitive function were evaluated by single factor Analysis and multiple linear stepwise regression analysis. Results: The scores of 11 sub-measures, such as knowledge, comprehension and arithmetic, were significantly lower in the study group than those in the control group (P <0.001). The VIQ, PIQ, The FIQ score was significantly lower than that of the control group (P <0.001). Correlation analysis showed that there was a significant correlation between FIQ and education, the number of antiepileptic drugs, the onset time and course of disease (R = 0.611), VIQ and education, antiepileptic drugs (R = 0.619), PIQ was significantly correlated with the time of onset, age, the number of antiepileptic drugs and educational level (R = 0.571). Conclusion: The incidence of cognitive impairment in patients with primary epilepsy is significantly related to education, age, course of disease, number of antiepileptic drugs, duration of attack and other factors.