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目的探讨氨酚羟考酮片预防前列腺2微米激光气化切除术后膀胱痉挛的临床疗效。方法选取2012年8月—2014年8月武警福建省总队医院需行手术治疗的良性前列腺增生患者82例,按入院顺序分为试验组(42例)与对照组(40例)。试验组患者术后6h予以氨酚羟考酮片治疗,对照组患者未进行预防性用药。观察两组患者术后7d内膀胱痉挛发生情况、膀胱痉挛持续时间及膀胱冲洗引流液转清时间。结果试验组患者膀胱痉挛发生率低于对照组,差异有统计学意义(P<0.05);试验组患者膀胱痉挛持续时间和膀胱冲洗引流液转清时间短于对照组,差异有统计学意义(P<0.05)。结论氨酚羟考酮片可降低前列腺2微米激光气化切除术后膀胱痉挛的发生率,缩短膀胱痉挛持续时间和膀胱冲洗引流液转清时间。
Objective To investigate the clinical efficacy of oxycodone hydrochloride tablets in preventing post-prostatectomy bladder spasm after 2-μm laser vaporization. Methods Eighty-two patients with benign prostatic hyperplasia who underwent surgical treatment at the Corps Hospital of Fujian Province from August 2012 to August 2014 were selected and divided into experimental group (n = 42) and control group (n = 40) according to admission sequence. Patients in the test group were treated with paracetamol 6 hours after operation and patients in the control group were not given prophylactic medication. The incidence of bladder spasm, the duration of bladder spasm and the time of bladder flush drainage were observed within 7 days after operation. Results The incidence of bladder spasm was lower in the test group than in the control group (P <0.05). The duration of bladder spasm and the time of clearing the bladder irrigation drainage fluid in the test group were shorter than those in the control group (P <0.05) P <0.05). Conclusion Oxycodone tablets can reduce the incidence of bladder spasm and reduce the duration of bladder spasm and bladder flushing drainage after prostatectomy 2 μm laser gasotomy.