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目的:应用左心室压力-应变环(PSL)评估蒽环类药物对乳腺癌患者心肌做功的影响。方法:选取2019年4月至2020年6月在哈尔滨医科大学附属第二医院术后行AC-T方案(多柔比星/表柔比星+环磷酰胺+多西他赛)的乳腺癌患者30例为病例组，另选取性别、年龄相匹配的30例健康者作为对照组。病例组分别于化疗前(T0期)、化疗后第3周期(T1期)及化疗后第6周期(T2期)进行超声心动图检查。采集常规超声参数，同时应用PSL技术采集心肌做功参数，包括整体做功指数(GWI)、整体有用功(GCW)、整体无用功(GWW)及整体做功效率(GWE)。与对照组比较，观察病例组T0期、T1期及T2期左室心肌做功参数的变化。结果:①病例组T0期与对照组临床资料、常规超声参数、左室应变及心肌做功参数差异无统计学意义(均n P>0.05)；②病例组T1期与T0期LVEF、GLS、GWI、GCW、GWE及GWW差异无统计学意义(均n P>0.05)；③病例组T2期与T0期LVEF差异无统计学意义(n P>0.05)，T2期GLS、GWI、GCW、GWE绝对值降低，GWW增高，差异有统计学意义(均n P0.05)，T2期GLS、GWI、GCW、GWE绝对值降低，GWW增高，差异有统计学意义(均n P0.05). ②There were no statistically significant differences of LVEF, GLS, GWI, GCW, GWE and GWW between T1 phase and T0 phase (alln P>0.05). ③There were no statistically significant differences in LVEF between T2 phase and T0 phase (n P>0.05). The absolute values of GLS, GWI, GCW and GWE decreased, but GWW increased, the difference was statistically significant (alln P0.05), but the absolute values of GLS, GWI, GCW and GWE decreased, while GWW increased (alln P<0.05).n Conclusions:Left ventricular PSL can effectively evaluate the myocardial work of anthracycline chemotherapy in breast cancer patients, which is superior to LVEF and provide a new evaluation method for asymptomatic patients.