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目的 探讨晚期食管癌放射治疗合并化疗的疗效和毒副反应。方法 对符合入组条件的 86例晚期食管癌随机分为 :综合组 46例 ,外照射同常规放射治疗组 ,放射治疗当日及外照射达DT40Gy时 ,同时合并化疗 ,化疗方案 :氟尿嘧啶 ( 5 -FU)5 0 0mg·d-1,5d ;顺铂 (DDP) 3 0mg·d-1,5d ;亚叶酸钙 (CF) 2 0 0mg·d-1,5d ;常规放射治疗组 46例 (单放组 )食管癌常规外照射总量DT60～ 64Gy/ 6～ 7周 ,每次 2Gy ,每周 5次。均采用 8MVX线照射。结果 全部病人随访 3年以上 ,随访率 98 4%。近期疗效完全缓解率综合组和单放组分别为 40 3 %和 2 9 0 % ( χ2 =1 2 6P >0 0 5 ) ;综合组和单放组的 1、2、3年生存率分别为 :72 5 8%、5 1 61%、3 7 10 %和 5 8 10 %、3 2 2 6%、2 0 97%。 2、3年生存率差异有显著性 (P <0 0 5 )。两组的毒副反应综合组高于单放组。结论 放疗合并DF方案加CF化疗优于单纯放疗 ,是治疗中晚期食管癌的一种有效方法
Objective To investigate the efficacy and side effects of radiotherapy combined with chemotherapy in advanced esophageal cancer. Methods Eighty - six patients with advanced esophageal cancer who were eligible for inclusion were randomly divided into four groups: the combination group (46 cases) and the external radiotherapy group (conventional radiotherapy group). On the day of radiotherapy and external irradiation of DT40Gy, chemotherapy combined with 5 - fluorouracil (5 - (DDP) 30mg · d-1, 5d; Calcium leucovorin (CF) 200mg · d-1, 5d; conventional radiotherapy group 46 cases (single Put the group) General external esophageal radiation DT60 ~ 64Gy / 6 ~ 7 weeks, each 2Gy, 5 times a week. All use 8MVX line irradiation. Results All patients were followed up for more than 3 years with a follow-up rate of 98.4%. The complete response rate and complete release rate were 40 3% and 29 0% respectively (χ 2 = 1 2 6 P> 0 05). The 1, 2, 3 year survival rates of the combination group and the radiotherapy alone group were : 72 5 8%, 5 1 61%, 3 7 10% and 5 8 10%, 3 2 2 6% and 2 0 97%. The difference of 2 and 3-year survival rates was significant (P <0.05). Toxicity in both groups was higher than in the combined group. Conclusion Radiotherapy combined with DF regimen plus CF chemotherapy is superior to radiotherapy alone and is an effective treatment for advanced esophageal cancer