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目的 研究甘露醇 ,维生素C、E联合治疗急性脑梗死的疗效。方法 用甘露醇、维生素C、E(MCE)联合治疗急性脑梗死 2 6 8例 ,用维脑路通静滴作为对照组治疗 172例 ,比较两组治疗前后 15天和 30天的神经功能缺损评分。随机抽取MCE组中 38例 ,对照组中 34例进行SOD及MDA测定 ,并比较入院当日及治疗 15天时的变化。结果 神经功能缺损评分MCE组治疗前 18 4± 6 8,15天为 10 2± 8 2 ,30天为 8 0± 5 6 ;对照组治疗前为17 8± 7 8,15天为 15 8± 6 8,30天为 13 8± 7 2。治疗 15天时MCE组明显优于对照组 (P <0 0 1) ,30天时也明显优于对照组 (P <0 0 1)。治疗 15天后MCE组及对照组SOD分别为 (98 36± 8 0 8) μU/L及 (88 48± 6 36 )μU/L ,MDA分别为 (4 2 8± 0 48) μmol/L和 (5 46± 0 36 ) μmol/L。两组比较差异非常显著 (P <0 0 1)。结论 MCE联合抗自由基治疗较传统的基础药物治疗后神经功能缺损评分减少明显 ,SOD值上升及MDA值下降亦明显。
Objective To study the efficacy of mannitol, vitamin C and E in the treatment of acute cerebral infarction. Methods A total of 268 acute cerebral infarction patients were treated with mannitol, vitamin C and E (MCE). 172 cases were treated with intravenous infusion of Venoruton as the control group, and the neurological deficits were compared between the two groups before and 15 days and 30 days score. Thirty-eight cases of MCE group and 34 cases of control group were randomly divided into two groups. The changes of SOD and MDA were compared, and the changes on the day of admission and on the 15th day of treatment were compared. Results The score of neurological deficit in the MCE group was 108 ± 8 2 at 18 4 ± 6 8 days and 80 ± 5 6 days at 30 days before treatment, 17 8 ± 7 8 days at 15 days before treatment in the control group, 6 8, 30 days was 13 8 ± 7 2. MCE group was significantly better than the control group on the 15th day (P <0.01), and was significantly better than the control group on the 30th day (P <0.01). After 15 days of treatment, the levels of SOD in the MCE group and the control group were (98 36 ± 8 0 8) μU / L and (88 48 ± 6 36) μU / L, respectively, and MDA levels were (428 ± 0 48) 5 46 ± 0 36) μmol / L. The difference between the two groups was significant (P <0.01). Conclusion MCE combined with anti-free radical therapy significantly reduced the score of neurological deficit compared with that of traditional medicine. The increase of SOD value and the decrease of MDA value were also observed.