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目的 探讨血红蛋白浓度与鼻咽癌放射治疗后生存率的关系。方法 1989年 1月至1998年 12月 30 4例接受鼻咽癌根治性放射治疗的病例 ,经病理证实 ,男性 2 0 9例 ,女性 95例 ,中位年龄 42岁 (16～ 77岁 )。采用60 Co或 6MVX射线放射治疗 ,鼻咽原发灶剂量 6 4～ 76Gy ,颈部淋巴结区剂量 46～ 77Gy。放射治疗前、中、后均测定血红蛋白量。放射治疗前根据血红蛋白浓度分 3个组 (<12 0g/L为贫血组 ,12 0～ 16 0g/L为正常组 ,>16 0g/L为高血红蛋白组 )。放射治疗后根据血红蛋白浓度变化分为 2个组 (血红蛋白升高组及血红蛋白降低组 )。结果 所有患者均随访 ,随访率 90 .5 %。血红蛋白的浓度明显影响鼻咽癌各期病例的生存率。放射治疗中血红蛋白量的升高及降低对鼻咽癌各期病例的生存率及局部控制率有影响。结论 血红蛋白浓度能影响血液中血氧含量 ,血红蛋白量升高可使鼻咽癌的局部控制率及远期生存率提高。
Objective To investigate the relationship between the hemoglobin concentration and the survival rate of nasopharyngeal carcinoma after radiotherapy. Methods From January 1989 to December 1998, 304 patients undergoing radical radiotherapy of nasopharyngeal carcinoma were confirmed by pathology. There were 209 males and 95 females with a median age of 42 years (range, 16-77 years). With 60Co or 6MV X-ray radiotherapy, the primary nasopharyngeal dose was 64-76 Gy and the cervical lymph node dose was 46-77 Gy. Radiotherapy before, during and after the determination of hemoglobin. According to hemoglobin concentration before radiotherapy, there were 3 groups (<120 g / L anemia group, 120 ~ 160 g / L normal group,> 160 g / L high hemoglobin group). After radiotherapy, hemoglobin concentration was divided into two groups (hemoglobin increase group and hemoglobin decrease group). Results All patients were followed up for 90.5%. Hemoglobin concentration significantly affects the survival of nasopharyngeal carcinoma in all stages. The increase and decrease of hemoglobin in radiation therapy have an impact on the survival rate and local control rate in all stages of NPC. Conclusion Hemoglobin concentration can affect the blood oxygen content. The increase of hemoglobin can increase the local control rate and long-term survival rate of nasopharyngeal carcinoma.